ea0038oc5.1 | Thyroid and parathyroid | SFEBES2015
Read Martin
, Smith Joel
, Smith Vicki
, Bosseboeuf Emy
, Wake Naomi
, Watkinson John
, Wallis Yvonne
, Maher Eamonn
, McCabe Christopher
, Woodward Emma
Whilst the majority of familial medullary thyroid cancer (MTC) is caused by germline mutations of the RET proto-oncogene, there are families and individuals with predisposition to MTC in whom no RET mutation has been identified (non-RET MTC). Recently, we identified novel mutations in a single gene termed MTC2 in non-RET MTC individuals by whole exome sequencing. The precise role of these MTC2 germline mutations in MTC tumorigenesis is however unclear. Here, we examined the fu...